Lindsay and Jenny, tourists from New York visiting Germany, get a flat tire on their way to a night club and seek help at the house of misanthropic, psychopathic surgeon Dr. Josef Heiter. He drugs the women with Rohypnol and kidnaps them to a makeshift medical ward. Heiter kills a kidnapped truck driver after Heiter informs him he is "not a match". Heiter also abducts Japanese tourist Katsuro. Heiter is a retired world-renowned expert at separating Siamese twins, but dreams of making new creatures by sewing humans together. He says he will surgically connect his three victims mouth-to-anus, so that they share a single digestive system. His prior experiment, the 3Dog, conjoined three Rottweilers into a "Siamese triplet." All three dogs expired after the operation. Heiter has moved on to using human subjects.

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Yawn.
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