The film opens with an unnamed dancer (Charles "Lil Buck" Riley) dancing in various locations around Brooklyn during the credit sequence.

From there, the plot follows Dr. Hess Green (Stephen Tyrone Williams), a wealthy African-American anthropologist and art collector who acquires a dagger originating in the ancient Ashanti Empire, a highly advanced civilization that, Green claims, became addicted to blood transfusions. That night, Lafayette Hightower (Elvis Nolasco), an emotionally unstable colleague from the museum which acquired the dagger, visits Green's impressive, African-art covered Martha's Vineyard mansion. The two cordially discuss history and philosophy, but once Green has retired for the evening, Hightower becomes drunk and climbs a tree with a noose, claiming he wants to commit suicide. Green successfully talks him down, but later that night Hightower attacks and stabs Green with the Ashanti ceremonial dagger, killing him. Sometime later, Green is shocked to awaken—unscathed. He hears a gunshot and, upon discovering that Hightower has killed himself, he instinctively drinks Hightower's blood. He discovers that he is invulnerable to physical harm, can no longer tolerate normal food and drink, and has an insatiable need for more blood. Though he steals several bags of blood from a doctor's office, he quickly finds that he needs fresh victims. The first is a prostitute Lucky Mays (Felicia Pearson) who, shockingly, reawakens—only after he has discovered that her blood is HIV-positive. After a period of tension, it is determined that he has not contracted the virus.

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Official Trailer
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Da Sweet Blood of Jesus (2014) | Official Trailer | HD |
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Da Sweet Blood of Jesus Official Trailer #1 (2014) - Spike Lee Movie HD
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