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Dr. James Marcus, the founder of the Umbrella Corporation, had a daughter, Alicia, who was dying of progeria. Desperate to save her, Marcus uses the T-virus on her and others with the disease. After another child treated with the virus died and then reanimated as a rabid zombie, Marcus tried to have the program shut down. His partner, Dr. Alexander Isaacs, had Marcus killed by Albert Wesker, then adopted Alicia and took over the Corporation.

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